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Teon targets metabolic signaling pathways to restore antitumor immunity and suppress cancer cell proliferation
Teon targets metabolic signaling pathways to restore antitumor immunity and suppress cancer cell proliferation

Teon Therapeutics is developing a portfolio of single-target small molecules that affect metabolic signaling pathways in the tumor microenvironment. Our pipeline consists of first-in-class and best-in-class candidates with targets that affect both immune and cancer cells.

Our Science

Cancer immunotherapies have demonstrated clinical efficacy in different types of cancer. However, many tumors show significant resistance to checkpoint blockade presumably due to insufficient rectification of the immunosuppressive tumor microenvironment (TME) and the limited reinvigoration of antitumor immunity.

Teon takes a unique approach to improve the TME and reinvigorate anticancer immunity:

  1. Targeting key GPCRs and enzymes in the TME that are upregulated on immune cells and cancer cells

  2. Developing a synergistic pipeline of first-in-class and best-in-class compounds across the TME metabolic signaling pathways

TME (Tumor Microenvironment)

Teon can antagonize metabolic pathways that suppress antitumor immunity and promote cancer cell proliferation

The immunosuppressive state of the TME is regulated by the metabolic activity of cancer cells. Rapidly proliferating cancer cells require high levels of energy and therefore metabolic reprogramming has emerged as a key feature for cancer survival under hypoxia, stress and limited nutrient availability. Metabolic reprogramming generates large amount of metabolites that not only alter the TME, adversely affect the survival and function of immune cells but also directly stimulate cancer cell proliferation. The common feature of this metabolic reprogramming is that cancer cells switch their glucose metabolism toward “aerobic glycolysis” (Warburg effect), thus decreasing glucose availability and increasing lactic acid in the TME. The hypoxic, glucose-deprived and lactic acid-enriched TME impairs T cell function and thus antitumor immune response. Metabolic stress leads to the release of the danger signal molecule ATP into the TME. ATP is rapidly converted to adenosine, which activates adenosine receptors (A2A and A2B) on immune cells and cancer cells and consequently inhibits immune function and promotes cancer cell survival. Aberrant lipogenesis is another key feature of metabolic reprogramming in cancer cells. While lipids provide additional energy required by proliferating tumor cells, their metabolites, such as prostaglandin E2 (PGE2), can dampen the function of immune cells through activation of EP4 receptors.

Pipeline
Candidate Target 1st-in-Class Indications Discovery Pre-clinical IND Phase 1/2
TT-702 A2BR CRPC
TNBC
CRC
     
TT-816 UDT1 TBA      
TT-038 EP4 TBA      
TT-228 A2AR TBA    
TT-015 UDT2 TBA  

Leadership

Alan Colowick, MD, MPH

Executive Chairman

Lina Yao, MD, PhD

Acting CEO & CSO

Robert Sikorski, MD, PhD

CMO

Ken Horne

Senior Advisor

Elfatih Elzein, PhD

VP, Chemistry & Early Development

Jim Liu, PhD

VP, Chemistry

Peter Fan, PhD

VP, Biology

Sami Karaborni, PhD

Head of Drug Development

Veronique Lauriault, PhD, DABT

Head of Toxicology

Steve Smith

Head of DMPK

Feng Deng

Lou Lange, MD, PhD

Lina Yao, MD, PhD

Alan Colowick, MD, MPH

Glen Giovannetti

Dave Chenn

Eric Small, MD

David Dornan, PhD

Brent Blackburn, PhD

Ivan Diamond, MD, PhD

News

Teon Therapeutics to Present Preclinical Proof of Concept Data at American Association for Cancer Research (AACR) Conference

Teon Therapeutics, a biopharmaceutical company developing small molecules that inhibit immunosuppressive and cancer-promoting signaling pathways, today announced the forthcoming oral presentation of preclinical data on selective adenosine A2B receptor antagonist TT-702, at the American Association for Cancer Research (AACR) Annual Meeting, held virtually from April 10-15, 2021.

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Cancer Research UK and Teon Therapeutics Advance New First-In-Class Cancer Drug Into Clinical Trial

Cancer Research UK and Teon Therapeutics, Inc. (Teon) today (Monday 1 March) announce that they have signed a collaboration agreement to progress the early phase clinical development of Teon’s first-in-class small molecule adenosine A2B receptor antagonist, TT-702.

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Teon Therapeutics Completes $30 Million Series A Financing

Teon Therapeutics, a biopharmaceutical company developing small molecules that inhibit the immunosuppressive and cancer-promoting signaling pathways, today announced the completion of a $30M Series A financing. The financing was led by Oceanpine Capital with participation from additional new investors Oriza Ventures, Lifespan Investments, and former Gilead senior executives.

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