Teon Therapeutics is developing a portfolio of single-target small molecules that affect metabolic signaling pathways in the tumor microenvironment. Our pipeline consists of first-in-class and best-in-class candidates with targets that affect both immune and cancer cells.
Cancer immunotherapies have demonstrated clinical efficacy in different types of cancer. However, many tumors show significant resistance to checkpoint blockade presumably due to insufficient rectification of the immunosuppressive tumor microenvironment (TME) and the limited reinvigoration of antitumor immunity.
Teon takes a unique approach to improve the TME and reinvigorate anticancer immunity:
Targeting key GPCRs and enzymes in the TME that are upregulated on immune cells and cancer cells
Developing a synergistic pipeline of first-in-class and best-in-class compounds across the TME metabolic signaling pathways
TME (Tumor Microenvironment)
Teon can antagonize metabolic pathways that suppress antitumor immunity and promote cancer cell proliferation
The immunosuppressive state of the TME is regulated by the metabolic activity of cancer cells. Rapidly proliferating cancer cells require high levels of energy and therefore metabolic reprogramming has emerged as a key feature for cancer survival under hypoxia, stress and limited nutrient availability. Metabolic reprogramming generates large amount of metabolites that not only alter the TME, adversely affect the survival and function of immune cells but also directly stimulate cancer cell proliferation. The common feature of this metabolic reprogramming is that cancer cells switch their glucose metabolism toward “aerobic glycolysis” (Warburg effect), thus decreasing glucose availability and increasing lactic acid in the TME. The hypoxic, glucose-deprived and lactic acid-enriched TME impairs T cell function and thus antitumor immune response. Metabolic stress leads to the release of the danger signal molecule ATP into the TME. ATP is rapidly converted to adenosine, which activates adenosine receptors (A2A and A2B) on immune cells and cancer cells and consequently inhibits immune function and promotes cancer cell survival. Aberrant lipogenesis is another key feature of metabolic reprogramming in cancer cells. While lipids provide additional energy required by proliferating tumor cells, their metabolites, such as prostaglandin E2 (PGE2), can dampen the function of immune cells through activation of EP4 receptors.
Alan Colowick, MD, MPH
Lina Yao, MD, PhD
Robert Sikorski, MD, PhD
Elfatih Elzein, PhD
Jim Liu, PhD
Peter Fan, PhD
Sami Karaborni, PhD
Veronique Lauriault, PhD, DABT
Lou Lange, MD, PhD
Lina Yao, MD, PhD
Alan Colowick, MD, MPH
Eric Small, MD
David Dornan, PhD
Brent Blackburn, PhD
Ivan Diamond, MD, PhD
Teon Therapeutics to Present Preclinical Proof of Concept Data at American Association for Cancer Research (AACR) Conference
Teon Therapeutics, a biopharmaceutical company developing small molecules that inhibit immunosuppressive and cancer-promoting signaling pathways, today announced the forthcoming oral presentation of preclinical data on selective adenosine A2B receptor antagonist TT-702, at the American Association for Cancer Research (AACR) Annual Meeting, held virtually from April 10-15, 2021.
Cancer Research UK and Teon Therapeutics Advance New First-In-Class Cancer Drug Into Clinical Trial
Cancer Research UK and Teon Therapeutics, Inc. (Teon) today (Monday 1 March) announce that they have signed a collaboration agreement to progress the early phase clinical development of Teon’s first-in-class small molecule adenosine A2B receptor antagonist, TT-702.
Teon Therapeutics Completes $30 Million Series A Financing
Teon Therapeutics, a biopharmaceutical company developing small molecules that inhibit the immunosuppressive and cancer-promoting signaling pathways, today announced the completion of a $30M Series A financing. The financing was led by Oceanpine Capital with participation from additional new investors Oriza Ventures, Lifespan Investments, and former Gilead senior executives.